Granny's Cherokee Casserole Recipe

Granny's Cherokee Casserole Recipe

Cook Time: 30 minutes

Ingredients

This recipe was developed at its original yield. Ingredient amounts are automatically adjusted, but cooking times and steps remain unchanged. Note that not all recipes scale perfectly.

  • 1 pound lean ground beef
  • 1 onion, finely diced
  • 1 (14.5 ounce) can diced tomatoes
  • 1 (10.5 ounce) can condensed cream of mushroom soup
  • 1 cup instant rice
  • 2 teaspoons white sugar
  • 1 tablespoon garlic powder
  • 1 teaspoon dried thyme
  • 1 teaspoon dried oregano
  • 6 slices American cheese

Directions

Step 1: Preheat the oven to 350F (175C).

Step 2: Place the ground beef and diced onion into a large, deep skillet. Cook over medium-high heat until the beef is evenly browned. Drain any excess fat.

Step 3: Add the diced tomatoes, condensed mushroom soup, rice, white sugar, garlic powder, thyme, and oregano to the skillet. Stir well to combine, then cook over medium heat for 10 minutes.

Step 4: Transfer the mixture into a 9x13-inch casserole dish.

Step 5: Arrange the slices of American cheese on top of the beef and rice mixture.

Step 6: Bake in the preheated oven for 15 to 20 minutes, or until the cheese is bubbling and slightly browned.

Nutrition Facts (per serving)

  • Calories: 241
  • Fat: 15g
  • Carbs: 13g
  • Protein: 12g

Nutrition Facts

Servings Per Recipe: 11

Nutrient Amount % Daily Value*
Total Fat 15g 19%
Saturated Fat 7g 35%
Cholesterol 46mg 15%
Sodium 523mg 23%
Total Carbohydrate 13g 5%
Dietary Fiber 1g 3%
Total Sugars 3g -
Protein 12g 25%
Vitamin C 5mg 6%
Calcium 101mg 8%
Iron 2mg 12%
Potassium 180mg 4%

* Percent Daily Values are based on a 2,000 calorie diet. Your daily values may be higher or lower depending on your calorie needs.

** Nutrient information is not available for all ingredients. Amount is based on available nutrient data.

If you are following a medically restrictive diet, please consult your doctor or registered dietitian before preparing this recipe for personal consumption.

FAQ about Granny's Cherokee Casserole Recipe

Yes, you can freeze this casserole. To do so, let it cool completely after baking, then cover it tightly with plastic wrap or aluminum foil and store it in an airtight container. It can be frozen for up to 3 months. To reheat, bake it from frozen at 350°F (175°C) for about 25-30 minutes, or until heated through.

Leftovers of Granny's Cherokee Casserole can be stored in the refrigerator for up to 3-4 days. Make sure to store it in an airtight container to maintain freshness.

Yes, you can use other types of rice, but keep in mind that the cooking time will change. If you use regular rice, you may need to cook it separately before adding it to the casserole to ensure it is fully cooked.

Absolutely! You can add vegetables such as bell peppers, zucchini, or corn to the casserole. Just make sure to adjust the cooking time accordingly, depending on the vegetables you add.

Yes, you can use any cheese you prefer. Cheddar, Monterey Jack, or mozzarella are great alternatives to American cheese. Just make sure the cheese melts well for the best texture.

Granny's Cherokee Casserole pairs wonderfully with a side of cornbread, a green salad, or steamed vegetables. You can also serve it with a dollop of sour cream or salsa for added flavor.

Yes, you can substitute the cream of mushroom soup with another creamy soup, such as cream of chicken or cream of celery. Alternatively, you can make a homemade creamy sauce using milk, butter, and flour.

Yes, you can make this recipe gluten-free by using a gluten-free cream of mushroom soup and checking that the rice you use is labeled gluten-free. Most rice varieties are naturally gluten-free.

If you don't have ground beef, you can substitute it with ground turkey, chicken, or even a plant-based ground meat alternative for a lighter or vegetarian version.

Yes, you can assemble the casserole ahead of time. Simply follow the recipe up until the point of baking, then cover it and refrigerate it for up to 24 hours. When you're ready to bake, just add the cheese and cook as directed.

Comments

LHUEZO

10/06/2025 01:52:54 PM

This recipe is a great base to add what you would like. I actually changed it up quite a bit. I used real rice that I cooked while I cooked the ground beef and onions and 'minced' garlic. I omitted the oregano, thyme, and sugar. I added a good amount of salt, pepper, and Red pepper flakes ground through a spice grinder very finely. I used a can of rotel tomatoes (milder) and Cream of mushroom with roasted garlic. I blended everything together and added about a cup of milk so it wouldn't dry out in the oven. I topped it with shredded "mexican" cheese and some shredded 5 Cheese italian. Baked it as directed. It was really good. You could do so much with this recipe. My hubby and I were talking about stuffing tortillas with it, toppin them with the cheese and your choice of salsa or enchilada sauce!!

PennyS

03/27/2011 05:28:50 PM

I have the original recipe which was published in a Minute Rice calendar for 1968. It includes a bay leaf (remove before eating) and 3 sliced stuffed olives (which add an interesting twist and are small enough for kids to eat around) --- and no sugar (where did that come from?). I swirl the tomatoes in the blender for a couple seconds as son hates tomatoes; they disappear nicely. We ate this from 1968 onward; still a hit with the next generation. I love it warmed up for several days after the first take. Amused to see it on this site.

Patti Duff Brown

03/07/2019 12:56:35 AM

I made this for dinner tonight. I omitted the sugar, and changed the spices around. I didn't use oregano, but I did use thyme and garlic powder. I also added a dash of cayenne pepper, some paprika, and salt. I used chili ready tomatoes, and I topped it with colby-jack cheese. Since I made corn muffins to go with it, I baked it at 400° for 10 minutes. I put it in the oven 5 minutes into the muffin baking time. I thought it was really good, and I would make it again.

Caleb-Sarah Weaver

03/26/2013 09:53:03 PM

This was way better than I thought it would be. I used cumin, paprika, salsa, and beef broth along with the rest. I cooked it all in the skillet on the stove. Delicious!

romans8_38-39

07/08/2015 07:30:29 AM

This was a great base! I know many get frustrated with reviews that deviate from the recipe, but I appreciate review variations that use ingredients I have on hand. I was looking for a way to use my abundant garden tomatoes. As I was dicing four 3" tomatoes, my 10-yr-old begged me to puree them instead. I used onion powder along with the garlic powder. I didn't have thyme or oregano. I covered the casserole with shredded cheese and my family loved it! My 10-yr-old even went back for seconds! She did add ketchup, but that's usual! I will be making this again~

Linda Farrell

06/06/2011 06:04:12 PM

This is so easy to prepare and so good tasting. I used 1 packet of instant brown rice, heart healthy cream of mushroom soup, Rotel tomatoes with green chilies and 1/2 tsp sugar. Everything else was according to the recipe. Next time, I will decrease the oregano a bit.

Cookinbob

04/07/2020 06:55:05 PM

My mother made this when I was a kid, and it has been "in our rotation" all my life. We use 3 Cups of cooked rice and an 8oz can of tomato sauce, no oregano or thyme, just salt and pepper. Really is comfort food, I like it with toast,

Writer2B

09/13/2004 07:50:20 PM

My husband is picky and he said this was a keeper! It does freeze well and if you need smaller portions just place casserole in two smaller baking dishes and freeze one. I used fresh garlic and subbed original Mrs. Dash for seasonings. Also subbed cheddar for american. Had no instant rice so added 2 cups of cooked rice but drained the tomatoes before adding. My daughter and I thought it was even tasty without the cheese. I like the stove top method idea. :)

TraciAndis

03/26/2008 04:45:27 PM

With a family of 6, I'm lucky to get half to like what I serve. THEY ALL LOVED THIS ONE. I added the garlic, and used colby-jack slices. Pepper Jack would be great too.

LORI L

02/01/2005 07:56:15 PM

As usual I needed something easy to make for dinner, and, as usual, I had very little time. Good thing I found this recipe. I did have some leftover cooked rice, and I used that instead of uncooked rice, so I didn't cook it for the 10 minutes before putting it in the oven. Also, I didn't have just plain oregano, so I used Italian seasoning instead. This was very good, and my family all decided I should make this again.

WOTKVLKE

02/27/2011 12:10:30 PM

Was suprised at how good this was. Very fast! I did use Rotel, shredded cheddar cheese and omitted the sugar. Also, it looked a little unappetizing so I added 3-4 drops of yellow food coloring and now tastes as good as it looks!

Jchirchi

07/11/2025 04:08:37 PM

The flavor was ok but the consistency was more like a filling than a main dish.

JoyfulSyrup8192

02/12/2025 03:50:42 PM

Great

FriskyPrawn3622

01/09/2025 05:17:53 PM

My mom made this for years and years and years, I could make this blindfolded. I enjoy this recipe and it brings back fond memories recipe is exactly like the one my mom has, thank you for this timeless dish.

Diane Martinez

01/06/2025 10:59:55 PM

Instant favorite in our house.

kovanda

09/08/2022 10:04:55 PM

Very good!!

Susan Hall

12/21/2020 09:24:27 PM

I must have done something wrong, did not like at all. Would have been a good idea to offer suggestions on sides. Won't make again, but my search continues.

Tulip

11/21/2020 12:06:38 AM

I made this tonight and thought it was just okay. If I make it again I'll add green pepper, and more rice.

Jaime Jorgenson

11/20/2020 01:44:56 PM

I had taken out some burger and didn't know what I was going to do with it. Came across this recipe and since I had everything on hand, gave it a try. Had 3 unexpected dinner guests and it was more than enough to feed 5 of us. I added a little seasoning salt, but otherwise followed the instructions. Everyone raved about it! Thank you!

Kevin

04/14/2019 10:34:32 PM

A nice and hearty dish! Really easy and quick to make, and super cheap too!