Italian Penicillin Soup Recipe
Sometimes the perfect cure for a cold or simply a long, tiring day is a steaming bowl of soup. Italian Penicillin Soup, also affectionately called Sick Day Soup or Chicken Pastina Soup, offers that warm comfort in abundance. This isn't your standard chicken noodle soup: the vegetables are simmered, pureed, and stirred back into the broth, giving it a rich, velvety texture. Cooking pastina directly in the soup adds just enough thickness, while fresh herbs and a Parmigiano-Reggiano rind take the flavor to a whole new level. Cozy, hearty, and soothing, this soup promises to become your favorite cold-weather companion.
Ingredients (Serves 6)
- 8 cups low-sodium chicken broth
- 2 cups chopped sweet onion
- 1 1/2 cups peeled and coarsely chopped carrots (about 2)
- 2 celery ribs, coarsely chopped
- 6 garlic cloves, smashed and peeled
- 3/4 teaspoon kosher salt
- 4 thyme sprigs
- 2 fresh bay leaves
- 1 (2-ounce) Parmigiano-Reggiano rind, plus extra for garnish
- 4 ounces uncooked pastina pasta
- 2 cups shredded rotisserie chicken
- Fresh flat-leaf parsley leaves for garnish
Instructions
- Gather all ingredients and prep vegetables.
- In a large saucepan or Dutch oven, combine chicken broth, onion, carrots, celery, garlic, and salt. Bring to a boil over high heat, then reduce to medium-low and simmer until vegetables are tender, about 10 minutes.
- Using a slotted spoon, transfer the vegetables and 1 cup of the broth to a blender. Secure the lid, remove the center piece to release steam, and cover with a clean towel. Blend until smooth, about 30 seconds.
- Stir the pureed vegetable mixture back into the soup. Add thyme sprigs, bay leaves, and the Parmigiano-Reggiano rind. Bring to a boil over medium-high heat.
- Add the pastina, reduce heat to medium-low, and simmer, stirring occasionally, until the pasta is tender, about 18-20 minutes. Add shredded chicken during the last 3 minutes of cooking.
- Remove from heat and discard thyme, bay leaves, and cheese rind. Serve immediately, garnished with parsley and grated Parmigiano-Reggiano.
Nutrition Facts (per serving)
- Calories: 332
- Fat: 13g (Saturated 4g)
- Cholesterol: 107mg
- Sodium: 1913mg
- Carbohydrates: 27g (Dietary Fiber 3g, Sugars 7g)
- Protein: 28g
- Vitamin C: 9mg
- Calcium: 157mg
- Iron: 2mg
- Potassium: 601mg
* Percent Daily Values are based on a 2,000 calorie diet. Values may vary depending on individual dietary needs.

The Origins and History of Italian Penicillin Soup
Italian Penicillin Soup, affectionately nicknamed "Sick Day Soup" or "Chicken Pastina Soup," has roots in traditional Italian home cooking. It emerged as a comforting remedy for colds and flu, combining nutrient-rich ingredients in a warming broth. While its exact origin is not documented, the practice of using chicken broth and finely chopped or blended vegetables as restorative food dates back centuries in Italian households, where mothers and grandmothers would prepare similar soups to nurture the sick or strengthen the weary.
Regional Variations Across Italy
This soup varies subtly depending on the Italian region. In northern Italy, cooks often add a Parmesan rind for depth and a richer broth, while in central regions, more emphasis is placed on fresh herbs such as thyme and parsley. Southern versions may incorporate garlic more prominently and sometimes include a touch of olive oil for added flavor. The use of small pasta shapes like pastina is typical, but regional adaptations may substitute tiny orzo or acini di pepe to suit local preferences.
Distinguishing Features Compared to Similar Soups
Unlike classic chicken noodle soup, Italian Penicillin Soup features blended vegetables that thicken the broth and create a smooth, velvety texture. The addition of a Parmesan rind and slow-simmered herbs sets it apart from simpler recipes. Pastina pasta cooks directly in the broth, absorbing flavors fully, rather than being boiled separately, which gives the soup a cohesive, hearty taste. These techniques make it both soothing and nutritionally satisfying, ideal for illness or comfort eating.
Typical Serving Context
Italian Penicillin Soup is most often served at home as a remedy for colds, flu, or just a cozy family meal on chilly days. It can also appear on menus in casual Italian trattorias or specialty restaurants that highlight traditional, rustic recipes. Often garnished with freshly chopped parsley and extra grated Parmesan, it is presented in bowls that invite immediate consumption while steaming hot, enhancing both aroma and experience.
Interesting Facts and Cultural Notes
- The nickname "Italian Penicillin" comes from its reputation as a natural, restorative dish capable of easing cold symptoms.
- Blending the vegetables was traditionally done to make the soup easier to digest, especially for children or the unwell.
- The recipe has been adapted worldwide, with many home cooks using rotisserie chicken for convenience, while purists insist on homemade chicken stock.
- Despite its medicinal nickname, it is a culinary creation celebrated for its flavor as much as its comfort properties.
- Modern variations sometimes include beans or spinach for added nutrition, showing the soups flexibility while retaining its classic character.
FAQ about Italian Penicillin Soup Recipe
Comments
Carla
10/06/2025 01:52:54 PM
It's missing the egg... ask any Italian Nonna. After you add the pastina and before you add the chicken, slowly drizzle in a beaten egg while stirring continuously. The residual heat will cook the egg and create a creamy texture to your soup. Also, if you don't want to drag out your blender, you can use an immersion blender and get the same results.
Michael Neiswender
02/05/2025 04:05:36 PM
Very nice recipe and blending the vegetables gives a rich mouth feel. Using packaged stock and rotisserie chicken are good ideas if your main goal is to make the soup quickly, but I would highly recommend making your own chicken stock from fresh whole chicken. If you have the time you can roast it first, then reserve roasted meat and make stock from the bones and remainder. You'll get a much better tasting and fresh result, and have some extra chicken meat and stock for another recipe. Cheaper too! :-)
David Taylor
01/09/2025 11:18:22 PM
Absolutely delicious — everyone loved it.
JovialMiso6049
02/05/2025 06:24:33 PM
For those of you questioning the validity of the use of lower sodium chicken broth and then the addition of kosher salt, you should consider this… Based on most brands of regular chicken broth containing around 850mg of sodium per cup, 8 cups would contain approximately 6,800mg of sodium. According to most low sodium chicken broth brands, 8 cups would contain approximately 2,240mg of sodium as a typical serving of low sodium chicken broth contains around 280mg of sodium per cup. Three-quarters of a teaspoon of kosher salt contains about 1,725 milligrams of sodium. Therefore the lower sodium chicken broth plus the kosher salt still equals about half the sodium in the regular chicken broth alone. By the way, recipes should be a guideline. The cook can always adjust amounts to the needs of their own family as well as omit things they see as extra or unnecessary. For instance, if i know my family is going to salt their individual bowl at the table, I’m free to use the lower sodium chicken broth and completely omit the kosher salt. Etc. Etc.
NiftyDuck2655
01/04/2025 10:35:35 PM
OMG, delish! I modified the process just a little. I pureed the cooked veg and pulsed the chicken thighs. I added two more bay leaves and extra garlic cloves. I also added 2 tbls of soy sauce for depth. This is so easy to make. Fills the kitchen with such yummy aroma...it was hard to wait for all the flavors to meld. Thank you for sharing. We love it!
Lori Levin
04/27/2025 04:22:43 PM
I thought the soup needed more body so I added a can of rinsed cannellini beans to food processor and soup. Came out great.
Sam
04/03/2025 09:43:56 PM
Very good! I think I added a little too much thyme, & I know I added extra pastina so my soup looks like stew. I tasted the blended mixture of veggies before adding it to my broth, and it’s delicious. . I did sauté some smaller pieces of celery, onion, & carrots & added it to my broth along with the pastina just because I like my soup chewy:) I discovered that I’m not a big fan of pastina, so I’ll probably use egg noodles next time. Thanks for sharing!
Jayne
04/02/2025 09:48:43 AM
Made me chuckle to see the use of ready made chicken broth, as this IS the base to make chicken broth😃. If you throw in a 1/2 organic chicken or capon and water instead of boxed broth, it’ far more nutritional than anything from the store, and the extra meat is great to use for chicken salad sandwiches. And this IS our staple for a true comfort meal, with or without pastina. Almost all good Italian pasta brands now offer no gluten as well.
maria
02/15/2025 07:54:03 PM
Followed the recipe closely. I did not add celery because I HATE celery! Yuck! Used my immersion blender. This was soooo good!! I will definitely do it again.
Jane Simons Haines
02/13/2025 01:48:14 PM
I couldn’t find fresh bay leaves, but the dried were fne. This is the best chicken soup I have ever had. I shared with my sisters and they couldn’t believe how good it was. I used an emulsifier in the pot instead of transferring the vegetables to a blender. My kitchen smelled so good all day!
Katie Dooley
03/09/2025 03:58:54 PM
Great recipe! I blend the veggies right in the soup pot using an immersion blender. I usually throw in some rough chopped fresh spinach in at the end. My family loves garlic, so I also add more of that. This recipe is a keeper!
mollymac22
09/21/2025 04:05:44 PM
My son is so picky, and hates the texture of veggies, but because I blend the veggies in this recipe- it’s the only chicken soup he will eat! It’s delish!
Janiece
09/13/2025 05:02:59 PM
This was perfect! My kids ate the whole pot and I doubled the recipe.
Beth
09/06/2025 08:34:45 PM
Now my go to chicken soup recipe! I have made so many different styles and this is my fave! I did add an egg..
UpbeatHoney1347
08/31/2025 01:35:19 AM
I put too much Pastina in but it's still delicious!
julienola0527
08/30/2025 11:11:15 AM
Absolutely delicious, so much depth of flavor and simple to make! Thanks for your delicious recipe!!!! C
Laura
08/20/2025 06:58:03 PM
I usually make it like the recipe and with broth but my boyfriend just made me some now since I'm sick and it is heavenly. It's thicker, like Gerber, but delish. I also asked for no chicken since chewing hurts. I just have to keep it away from our kitten bc she loves it too and garlic and onions are toxic for cats.
Phyllis Piccola
08/08/2025 05:40:00 PM
Same as when I was a child but without the chicken!
Becki
07/25/2025 06:18:42 PM
All of you all complaining about store bought broth need to lighten up. Not everyone has the time to roast a whole chicken, and then spend two days making the stock. I don't care how your Italian grandmother made it, this is a simple recipe that's basic enough for everyone.
tamaradt
05/07/2025 11:49:24 PM
This Italian version of the US’s chicken noodle soup may be even better!!!